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KMID : 0603520000050040175
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 4 p.175 ~ p.185
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Cancer Prevention by Tetrahydrocurcumin, a Novel Hydrogenated Derivative of Curcumin, in an in vivo Medium-term Multiorgan Bioassay
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Park Cheol-Beom
Kim Dae-Joong
Lee Joon-Sup
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Abstract
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The chemopreventive effects of tetrahydrocurcumin (THC), a newly synthesized derivative of curcumin, in an in vivo medium-term multiorgan carcinogenesis model were examined. One hundred sixteen male F344 rats were treated with diethylnitrosamine, azoxymethane, N-nitrosomethylbenzylamine or vehicles only at weeks 0, 1-2, and 3-5 respectively. Rats of group 1 and 2 were then given THC (0.5% or 0.25% in diet) for 33 weeks (7∼40 wk), whereas rats of group 2 and 4 were given basal diet for 40 weeks (0∼40 wk). All surviving animals were sacrificed at week 40 and the major organs, including the liver, lung, kidney, esophagus, and colon, were histologically examined. The incidences of lung and colon adenoma and adnocarcinoma combined in group 1 receiving 0.5% THC were significantly decreased as compared to the group 2 values (P＜0.05). Also the incidences of lung adenomas in group 1 decreased as compared to the group 2 values (P＜0.05). No effects were observed for liver and esophageal tumor incidences. The results suggest that THC exerts a chemopreventive effect on lung and colon carcinogenesis when given in the post-initiation stage to F344 rats.
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KEYWORD
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Multiorgan carcinogenesis, Tetrahydrocurcumin (THC), Chemoprevention
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